Biomaterial-mediated delivery of degradative enzymes to improve meniscus integration and repair
نویسندگان
چکیده
منابع مشابه
Degradative enzymes in osteoarthritis.
A central feature of the osteoarthritic disease process involves erosive destruction of the articular cartilage extracellular matrix (ECM) on the surfaces of diarthrotic joints. The resultant loss of joint function makes studies on mechanisms underlying ECM degradation critical for treatment of the disease and prevention of disability. Candidate pathways to account for the loss of cartilage inv...
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Introduction Meniscus tears are one of the most common indications for arthroscopic surgery, but the limited healing of adult meniscus directs clinical practice towards resection (partial meniscectomy) rather than repair, increasing the risk for early-onset osteoarthritis. As such, methods to augment endogenous repair could promote long-term joint health after injury. Previously, we showed that...
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This open-access article is published and distributed under the Creative Commons Attribution NonCommercial No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article witho...
متن کاملMarrow stimulating technique to augment meniscus repair.
Several techniques exist to increase the rate of healing of meniscal tears after repair. We describe a simple arthroscopic technique of microfracture to the intercondylar notch. This technique can provide marrow elements to the site of meniscus repair to aid in meniscal healing at the time of repair.
متن کاملTissue Engineered Meniscus Repair
Objective. Studies have shown that meniscal repairs have better outcomes over both partial and total meniscectomies. Tissue engineering strategies to repair meniscus tears have been explored using cell sources that involve a donor as well as a period of in vitro cell expansion before use. This study explored cell sources that could be easily harvested and rapidly isolated by enzymatic digestion...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2013
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2013.01.016